A fishing trip lands Robert in some very hot water when he falls unconscious and has trouble breathing. And 35-year-old Graeme has a rare disease that is attacking bone in some parts of his body.

Twenty-six-year-old Roumi is concerned about a lump in her neck that has been growing rapidly, and Fiona comes to RPA in the hope of a normal life, suffering from debilitating vertigo and deafness in one ear.

Twenty-six-year-old Erin arrives in RPA's emergency department in severe pain and struggling to breathe. Plus, a scan has uncovered a tumour on Cevat's spine that threatens to crush his spinal cord.

Con has two basal cell carcinomas. One is quite small, but he has neglected the other one for 12 years. He realises now that it may kill him if it is left untreated. He is told he will have to endure 14 hours of surgery to be rid of it. Plus, three-year-old Thelo is brought into emergency after falling at day care and hitting his head.

In part two of Gemma's story, she and her husband Stephen, say goodbye to their daughters knowing the risks involved in going ahead with the surgery.

Gemma's liver is failing but instead of waiting for a deceased donor liver, she is turning to her husband for help. If the operation goes ahead, it will be the second of its kind performed in Australia. Gemma's husband Stephen and his surgical team are assessing the pros and cons of giving part of his liver to save Gemma's life.

Jodie is about to endure her 22nd operation for arthritis and she's only 38. The hairdresser and mother of two lives in constant pain and is hoping that this next round of surgery will give her some relief. The plan is to fuse her ankle, and if time allows during the operation, and there is not too much blood loss, her toes will be fused as well.

The operation begins to remove Rupeni's kidney in part two of Fijian teenager Milise's amazing story. Meanwhile, over the past two months Roger has noticed his voice changing. Investigations have revealed a squamous cell cancer on his vocal cord, and Roger is opting for laser surgery to spare his larynx and, hopefully, improve his voice.

April has only just married but has had to put her future on hold while she deals with a painful lesion on her liver. Doctors won't know what it is until they remove it; however, removing it puts the liver at huge risk.

Zoo volunteer Betty, 73, has been feeling unwell for some time, and a scan has turned up the biggest spleen her doctors have ever seen. Weighing an estimated 2kg, it has to come out.

Twenty-three-year-old flight attendant Julie has brain surgery to remove two cancerous tumours on her brain, and 79-year-old Jimmy arrives in emergency suffering severe chest pains and must have major heart surgery in order to save his life.

Girolamo, 79, has a 5.5cm aneurysm in his belly which could rupture without warning, killing him instantly. However, after major surgery to have it repaired, he is raced back to the operating theatre with a mysterious and life-threatening complication.

When Renee knocked herself unconscious while skiing last winter, the young mother of two small children, could not have predicted what would happen next. A follow up scan revealed a large mass in her brain. In part one of her extraordinary story, Renee is told that she will need major brain surgery to remove the mass and she won't know what she is...